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Single-State Design
Design strands intended to adopt a target secondary structure at equilibrium.
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| Specify a single-state design problem. | |
| Specify a single-state design problem using advanced options, including sequence constraints. | |
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Multi-State Design
Design strands intended to adopt different target secondary structures in different complexes. This capability is useful for designing nucleic acid reaction pathways.
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| Specify a multi-state design problem. | |
| Specify a multi-state design problem using advanced options. | |
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Concentration-Based Design
Design strands intended to adopt target secondary structures at target concentrations in one or more
dilute solutions (e.g., test tubes). This is the next-generation multi-state formulation for
designing reaction pathways. The ability to specify concentrations is useful for ensuring that a
target structure dominates not only the ensemble of the complex in which it is found, but also
other competing off-target complexes that can form in a dilute solution.
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| Specify a single-state concentration-based design. | |
| Specify a multi-state concentration-based design. | |
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External Sequence Constraints
Design strands that incorporate domains from existing source sequences. This capability is useful for designing systems that interact with biological sequences.
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| Specify a multi-state design problem using external sequence constraints. | |
| Specify a multi-state design problem using external sequence constraints and advanced options. | |
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